Nerve pain and neuropathy can be incredibly challenging to endure, as they bring about a range of distressing sensations and pose significant obstacles to daily life. Those who suffer from nerve pain often describe it as a burning, shooting, or electric shock-like sensation that can occur spontaneously or in response to even the slightest touch. This pain can be relentless, making it difficult to find relief or engage in normal activities.
Neuropathy, a condition that affects the peripheral nervous system, can lead to a myriad of symptoms. It commonly manifests as tingling or numbness in the affected areas, such as the hands, feet, arms, or legs. These sensations can disrupt normal functioning and create a sense of detachment from one’s own body. Simple tasks like walking, typing, or holding objects may become arduous due to the loss of sensation or the presence of constant pain.
What makes nerve pain and neuropathy particularly challenging is their complex nature. They can arise from a variety of causes, including underlying medical conditions like diabetes, autoimmune disorders, or nerve injuries. Pinpointing the exact source of the pain can be a daunting task for healthcare professionals, as it often requires thorough diagnostic assessments and targeted treatment approaches.
Furthermore, nerve pain and neuropathy may not respond well to traditional pain medications, making effective management a significant hurdle. These conditions often involve alterations in the way nerves transmit signals, resulting in abnormal sensitivity or malfunctioning pain modulation. Treating nerve pain and neuropathy requires a comprehensive understanding of the underlying mechanisms and the implementation of personalized treatment strategies.
Given the debilitating impact of nerve pain and neuropathy on an individual’s quality of life, ongoing research and advancements in medical science are focused on finding innovative solutions to address these challenges. By unraveling the intricate workings of the nervous system and developing targeted therapies, medical professionals strive to offer effective relief and restore a sense of normalcy for those affected by nerve pain and neuropathy.
Rainforest Resin Shows Promise in Nerve Pain & Neuropathy
In recent scientific research, a substance called sangre de grado has shown promising effects in alleviating various inflammatory conditions. This article aims to delve into the science behind the action of sangre de grado, focusing on the role of protease and peptide receptor 2 (PAR2) in the body’s inflammatory response. By understanding these mechanisms, we can shed light on why sangre de grado may be effective in treating inflammation-related disorders.
The Role of Protease and Peptide Receptor 2: Proteases are enzymes that play essential roles in numerous physiological processes within the body. They regulate various cellular functions, including digestion, blood coagulation, and immune responses. However, when proteases become dysregulated or excessively activated, they can contribute to inflammation.
One crucial mediator of inflammation is a specific type of protease called protease-activating peptide receptor 2 (PAR2). PAR2 is a receptor found on the surface of various cells, including those involved in the immune and nervous systems. When activated by proteases, PAR2 triggers a cascade of signaling events that ultimately lead to increased inflammation, pain, and swelling.
Understanding Sangre de Grado’s Mechanism of Action:
Sangre de grado, a traditional medicinal resin derived from certain Amazonian trees, has long been used by indigenous communities to alleviate various ailments. Recent scientific investigations have sought to elucidate the active components and understand how sangre de grado exerts its anti-inflammatory effects.
In a study conducted on rat mesenteric arteries, researchers observed vasorelaxation (the relaxation of blood vessels) in response to calcitonin gene-related peptide (CGRP). Importantly, when diluted sangre de grado was introduced, it caused a shift in the CGRP dose-response curve, indicating its ability to modulate the effects of CGRP.
Furthermore, in experiments using rats, paw edema (swelling) induced by PAR2-activating peptide was significantly reduced by topical application of a sangre de grado balm. The balm containing a 1% concentration of sangre de grado demonstrated sustained effectiveness for at least 6 hours. Additionally, the balm was found to alleviate hyperalgesia (increased sensitivity to pain) caused by low-dose PAR2-activating peptide or prostaglandin E2.
Isolation and Identification of Active Components: To identify the specific active components responsible for sangre de grado’s effects, researchers fractionated the parent botanical. Through rigorous analysis using high-performance liquid chromatography and gas chromatography-mass spectrometry, they isolated a fraction possessing analgesic and capsaicin antagonistic properties.
The analysis revealed that the active fraction consisted of proanthocyanidin oligomers. These compounds are antioxidants have been previously associated with anti-inflammatory and exhibit different antioxidant properties, making them potential contributors to sangre de grado’s therapeutic effects.
Clinical Trials and Pest Control Worker Study:
To evaluate the practical applications of sangre de grado, a clinical trial was conducted involving pest control workers. The workers frequently encounter insects such as wasps, fire ants, mosquitoes, and bees, leading to itching, pain, discomfort, swelling, and redness.
During the trial, workers reported significant relief within minutes after applying a sangre de grado balm (marketed as Zangrado) compared to a placebo. The balm effectively alleviated the symptoms associated with insect bites, as well as cuts, abrasions, and plant reactions.
The scientific investigation into sangre de grado’s anti-inflammatory properties has provided valuable insights into its mechanism of action. By modulating the effects of protease and PAR2 activation, sangre de grado demonstrates the potential to alleviate inflammation, pain, and swelling.
The isolation and identification of proanthocyanidin oligomers further elucidate the active components responsible for sangre de grado’s effects. These compounds possess analgesic and capsaicin antagonistic properties, adding to the understanding of sangre de grado’s therapeutic potential.
Clinical trials involving pest control workers have shown that sangre de grado balm provides rapid relief from various insect bites and skin reactions. The positive outcomes reported by the workers support the ethnomedical use of sangre de grado for conditions characterized by neurogenic inflammation.
While further research is necessary to fully understand the molecular mechanisms and optimize sangre de grado’s use, the current scientific evidence demonstrates its potential as a natural therapeutic agent for inflammation-related disorders.
Can Sangre De Grago Be Used Topically & Internally?
Sangre de grado is a resin from a tree in the Amazon rainforest region. It is comprised mostly as a dense source of ORAC (oxygen radical absorbance capacity) antioxidants. This simply means that it has the capacity to act as an antioxidant repelling the oxidative effects of aging, stress, inflammation and pain. It works to counteract these things.
This resin is used both topically and internally. Topically it can be used as a solution for specific areas, but isn’t utilized as valuable as internally because internally it works throughout the entire body and is not wasted as a percentage of it is when used topically. Internally it also supports the health of the gut lining which helps to increase nutrient absorption when breaking down any calories consumed. This is helpful to sustain healthier levels of nutrition in the body as a whole.
A formula called Radiate 21 includes both Sangre De Grado and Una De Gato which are both native to the Amazon rainforest region. Both support the heart and cardiovascular system as a whole, and both have exhibited anti-inflammatory properties in multiple scientific studies from different organizations.
Radiate 21 brings together the powerful nerve protection properties of Sangre de grade with the powerful anti-inflammatory and red blood cell healing properties of una de gato. Together these two herbs can actually help to heal the cells, nervous system and support cardiovascular system all the while reducing pain and inflammation.
Click here to visit Radiate21.com today to benefit from Sangre De Grado, Una De Gato and 19 other powerful botanicals that reduce pain, inflammation, swelling and support the health of the nerves, cells, blood and lypmhatic system as a whole.